- #Non compartmental analysis with winnonlin professional#
- #Non compartmental analysis with winnonlin download#
Moreover, although the documentation describing the actual analysis algorithm used to process non-numeric data is not easily accessible to users, users may introduce numeric data at time zero to perform NCA properly. According to the results of this study, SimBiology estimates parameters using the unweighted linear regression for the terminal slope and linear interpolation method. Therefore, we conducted NCAs with a hypothetical dataset and some scenarios and compared the results. One of MATLAB's tools, SimBiology®, is often used for pharmacokinetic, pharmacodynamic model and dynamic systems however, SimBiology seems to be rarely used for non-compartmental analysis (NCA), and the published official documentation provides a poor description of the analysis algorithm for NCA.
#Non compartmental analysis with winnonlin professional#
Keep in mind that this is a professional report that is intended to be submitted to the FDA in support of filing a new drug application for approval. Interpretation of the results is fundamental to this final project. Your manager will expect you to make study conclusions that are supported by the data and can be used to support patient dosing information. The expectations of your manager are that you accurately conduct the PK analysis based on the analysis plan below, create the tables and figures as planned and write up a high quality PK report that documents all the findings from the clinical study and presents data in a clear and concise manner. Create tables and figures and describe the findings in your report.
#Non compartmental analysis with winnonlin download#
Read the study design, analysis plan below and conduct a noncompartmental analysis in Phoenix WinNonlin using the PK merge file Download PK merge filereceived. You are a clinical pharmacokineticist working for Company Y, you are responsible for analyzing and reporting pharmacokinetic data from this renal impairment study.